Indications
Acetylcysteine is used as a mucolytic agent in the adjunctive treatment of patients with inspissated mucous secretions in such conditions as acute and chronic bronchopulmonary disorders.
Acetylcysteine is used as an antidote for the treatment of paracetamol overdosage.
Contraindications
Known hypersensitivity to acetylcysteine or any ingredient in the preparation.
Patients with asthma or a history of bronchospasm.
Children under 2 years old.
Compositon/Ingredients
Acetylcystein 200mg
Dosage and administration
Mucolytic effect: Use as granules dissolved in water.
- Adults: 200 mg (1 capsule) three times daily.
- Children aged 3 to 6 years old: 200 mg (1 capsule) twice daily.
Antidote for paracetamol overdosage:
An initial dose of 140 mg/kg as a 5% solution followed by 70 mg/kg every 4 hours for additional 17 doses. Acetylcysteine is reported to be very effective when administered within 8 hours of paracetamol overdosage, with the protective effect diminishing after this time.
Precaution
Since oral administration of acetylcysteine may result in vomiting or aggravate vomiting associated with paracetamol overdosage, patients at risk of gastric hemorrhage should be evaluated with regard to the relative risks of upper gastrointestinal hemorrhage and paracetamol-induced hepatotoxicity and treatment with acetylcysteine given accordingly.
Asthmatic patients receiving acetylcysteine should be observed closely during such therapy; if bronchospasm occurs, a bronchodilator should be given by nebulization. If bronchospasm progresses, acetylcysteine should be discontinued immediately.
An increased volume of liquefied bronchial secretions may develop after administration of acetylcysteine. If cough is inadequate to maintain an open airway during acetylcysteine therapy, mechanical suction or endotracheal aspiration should be instituted.
Acetylcystein 200mg Vidipha can be used for pregnant and nursing women.
Patients should be aware of how they react to Acetylcystein 200mg Vidipha before driving or operating machinery.
Storage
Store at temperature below 30°C, protect from light.
