Acyclovir Stella 200mg (10 blisters x 5 tablets/box)

Indications

Treatment of Herpes simplex virus (HSV) infections

• Treatment of initial and recurrent HSV infection (type 1 and 2) in mucosa – skin (stomatitis, genital inflammation), in eye (keratitis).
• Prophylaxis of HSV infection in mucosa – skin when recurrences occur at least 6 times a year, in eyes (recurrent keratitis occur after twice a year) or in eye surgery.

Treatment of Varicella zoster virus infection (VZV)

• Herpes zoster, prophylaxis of complications in eye due to zoster in eye.
• Chickenpox in patients more than 2 years of age.

Contraindications

Patients who develop hypersensitivity to acyclovir or valacyclovir.

Compositon/Ingredients

Dosage and administration

• Primary HSV infections, including genital herpes: 200 mg five times daily every 4 hours for 5 – 10 days. Severely immunocompromised patients or those with impaired absorption: 400 mg five times daily for 5 days
• Suppression of recurrent HSV in immunocompetent patients (³ 6 times/year): 800 mg daily in 2 or 4 divided doses. Reassessment should be performed after 6 – 12 months of treatment.
• Prophylaxis of HSV in immunocompromised patients: 200 to 400 mg four times daily.
• HSV infection in eyes: Keratitis: 400 mg x 5 times/day in 10 days. Prophylaxis of recurrence of keratitis (after 3 recurrences a year): 800 mg/day in 2 divided doses. Reassessment should be performed after 6 – 12 months of treatment. Eye surgery: 800 mg/day in 2 divided doses.
• Herpes zoster: Adults and children > 2 years: 800 mg five times daily may be given for 5 to 10 days.
• Chickenpox: Adults: 800 mg four or five times daily for 5 to 7 days. Children > 2 years: 20 mg/kg, not more than 800 mg four times daily for 5 days. Children from 2 to 5 years: 400 mg four times daily. Children ≥ 6 years: 800 mg four times daily.
• Renal impairment associated with HIV experienced hemodialysis: 200 – 800 mg every 6 – 8 hours (ClCr 50 – 80 ml/min), every 8 – 12 hours (ClCr 25 – 50 mL/min), every 12 – 24 hours (ClCr 10 – 25 mL/min); 200 – 400 mg every 24 hours (ClCr < 10 mL/min); add 1 dose immediately after hemodialysis.

Precaution

• Elderly patients and patients with renal impairment are at increased risk of developing neurological side effects and should be closely monitored.
• Pregnancy (only if the potential benefit justifies the potential risk). Nursing mother (only when indicated).
• Patients should be aware of how they react to drug before driving or operating machinery.

Storage

Store at temperature below 30°C, protect from light.