Indications
Prevention of endocarditis or infection due to surgical implant in patients who are allergic to penicillin or in patients who have been on long-term penicillin treatment.
Lung abscess, severe respiratory tract infections caused by anaerobes, Streptococci, Staphylococci and Pneumococci. Intra-abdominal infections such as peritonitis and intra-abdominal abscess.
Suppurative wound infections (surgical or traumatic).
Puerperal fever (genital tract), severe infections of female pelvic and genital tract such as endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis and postsurgical vaginal cuff infection caused by anaerobes.
Contraindications
Patients previously found to be sensitive to clindamycin, lincomycin or to any component of the formulation.
Compositon/Ingredients
Clindamycin 300mg
Dosage and administration
Adults: Every 6 hours, 150 to 300mg (or 450mg in severe infections).
Children: 3 to 6mg/kg, every 6 hours.
Those under one year old or weighing less than 10kg: 37.5mg every 8 hours, the oral solution may be appropriated.
Prevention of endocarditis or infection due to surgical implant: 600mg (10mg/kg for adult dose) orally 1 – 2 hours before surgical procedure, followed by 300mg (5mg/kg) orally 6 hours after surgical procedure.
Puerperal fever (genital tract): For the women who are febrile but not clinically ill, suitable empirical treatment is amoxicillin + clavulanic acid, but if fever persists for longer 48 hours, clindamycin 300mg orally, every 8 hours (if there is Mycoplasma) until fever resolved or erythromycin 500mg orally (if there is Ureaplasma).
Precaution
Stop Clindamycin EG 300mg immediately if significant diarrhoea or colitis occurs.
Clindamycin EG 300mg should be used with caution in: Patients with a history of gastrointestinal disease, particularly colitis (middle-aged and elderly female patients); Atopic patients; Patients with a history of colitis. Periodic tests of liver and kidney function and blood counts have been recommended in patients receiving prolonged therapy, and in infants.
Dosage adjustment is recommended and periodic liver enzymes tests should be carried out in patients with severe hepatic impairment.
Clindamycin EG 300mg should be used only when clearly needed.
Breast-feeding should be avoided during therapy of drug.
Patients should be aware of how they react to drug before driving or operating machinery.
Storage
Store at temperature below 30°C, protect from light.
