Glucophage XR 750mg (2 blisters x 15 tablets/box)

Indications

Non-insulin-dependent diabetes mellitus (type II): Monotherapy when hyperglycemia cannot be managed on diet alone or in combination with sulfonylurea when diet and metformin or sulfonylurea alone does not result in adequate glycemic control.

Contraindications

• Known hypersensitivity to any of the active substance or excipients.
• Acute catabolic states, infection, trauma which should be treated with insulin.
• Decreased kidney function in renal disease or renal dysfunction (ClCr ≥ 1.5 mg/dl in males, or ≥ 1.4 mg/dl in females) or result from other diseases.
• Severe renal impairment (eGFR < 30 mL/minute/1.73 m²).
• Metabolic acidosis, including diabetic ketoacidosis.
• Severe hepatic/cardiovascular disease, severe respiratory disease with hypoxaemia.
• Congestive heart failure, cardiovascular collapse, acute myocardial infarction.
• Chronic hypoxic lung disease.
• Severe infection, septicemia.
• In acute symptoms of metabolic decompensation.
• Pregnancy.
• Temporarily withheld in patients undergoing radiologic studies involving the parenteral administration of iodinated contrast materials.
• Gangrene, alcoholism, malnutrition.

Compositon/Ingredients

Dosage and administration

Read carefully the leaflet before use. For further information, please consult doctor or pharmacist.

Precaution

• Risks of lactic acidosis (increase by the severity of renal impairment, age, alcohol intake).
• Therapy with metformin should be discontinued for any surgical procedures.
• Oral antidiabetic drugs increase cardiovascular mortality as compared to the treatment with diet alone or the combination of insulin with diet.
• A decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
• Patients should be aware of how they react to drug before driving or operating machinery (if metformin is used in combination with other antidiabetic agents).

Storage

Store at temperature below 30°C, protect from light.