Indications
Amlodipine is used alone or in combination with other classes of antihypertensive agents in the management of hypertension.
Amlodipine also is used for the management of Prinzmetal variant angina and chronic stable angina pectoris.
The drug has been used alone or in combination with other antianginal agents.
Contraindications
Patients who are hypersensitive to amlodipine, to any other calcium antagonist, or any ingredient in the formulation.
Compositon/Ingredients
Amlodipine 5mg
Dosage and administration
Hypertension Adults: The usual initial dosage of amlodipine is 2.5 – 5mg once daily. In geriatric and small frail individuals, an initial dosage of 2.5mg once daily is recommended. Subsequent dosage of amlodipine should be adjusted according to the patient’s blood pressure response and tolerance and usually should not exceed 10mg once daily. The usual maintenance dosage of amlodipine for the management of hypertension in adults is 5 –10mg once daily.
Children 6 years of age and older: The usual effective dosage of amlodipine is 2.5 – 5mg once daily. Angina For the management of Prinzmetal variant angina or chronic stable angina, the usual adult dosage is 5 –10mg once daily. In geriatric patients, the lower dosage of 5mg once daily is recommended. Maintenance dosage is 10mg daily.
Precaution
Amlodipine should be used with caution in patients with hypotension, cardiac reserve is poor, heart failure
The drug should not be used in cardiogenic shock, in patients who have suffered a myocardial infarction in the previous 2 to 4 weeks, or in acute unstable angina, in treatment an anginal attack in chronic stable angina. In patients with severe aortic stenosis amlodipine may increase the risk of developing heart failure. Sudden withdrawal of amlodipine might be associated with an exacerbation of angina. The dose may need to be reduced in patients with hepatic impairment.
Amlodipine should not be administered during pregnancy, or lactation, or to women of childbearing potential unless effective contraception is used.
Patients should be aware of how they react to drug before driving or operating machinery.
Caution is recommended especially at the start of treatment.
Storage
Store at temperature below 30°C, protect from light.
