Indications
An anti-inflammatory or immunosuppressive treatment for some diseases including causes due to hematology, allergies, arthritis, cancer and autoimmune.
Contraindications
Known hypersensitivity to any of the active substance or excipients. Serious infections, except septic shock and tuberculous meningitis. Viral, fungal, or tubercular skin lesions. Administration of live virus vaccines.
Compositon/Ingredients
Methylprednisolone 4mg
Dosage and administration
Adult: initial dosage from 2 – 60 mg daily in 4 divided doses.
Children: based on the severity of the disease and the response, after a satisfactory response is obtained, dosage should be decreased in small decrements to the lowest level that maintains adequate clinical response.
When long-term use: consider an alternate day dosage regimen, then withdrawn gradually.
Contact dermatitis: 24 mg (6 tablets of 4 mg) for the first day, then tapered by 4 mg daily until 21 tablets have been administered for 6 days (6, 5, 4, 3, 2, 1 is the amount of tablets administered from the first day to the sixth day respectively).
Asthma:
- Children < 4 years old (more than 3 exacerbations per year) and children 5 – 11 years old (at least 2 exacerbations per year): 1 – 2 mg/kg/day (maximum 60 mg daily) may be added to existing asthma therapy.
- Adults and adolescents (at least 2 exacerbations per year): 40-60 mg daily as a single dose or in 2 divided doses, may be added to low-to-high maintenance dosages in the inhaled corticosteroid and a long-acting inhaled b2-agonist bronchodilator, a short course (usually 3 – 10 days) of oral corticosteroid therapy should be continued until the patient achieves a peak expiratory flow (PEF) of 80% of his or her personal best and until symptoms resolve. Once asthma is well controlled, repeated attempts should be made to reduce the oral corticosteroid dosage.
Precaution
Patients with osteoporosis, newly established anastomoses, psychosis, gastric ulcer, duodenal ulcer, diabetes, hypertension, cardiac insufficiency and growing individuals (children), hepatic failure, renal failure, glaucoma, thyroid disease, cataracts.
Elderly: Should be used cautiously with the smallest possible dose, and for the shortest possible time.
The use of Medrol 4mg in pregnant women requires that the anticipated benefits of the drug should be weighed against possible hazards to the mother and the child.
Caution is advised when use Medrol 4mg in nursing women.
Acute adrenal insufficiency may occur with abrupt withdrawal after long-term therapy or with stress.
High doses can interference with vaccination.
Storage
Store at temperature below 30°C, protect from light.
