Indications
- Reducing the risk of nonsteroidal anti-inflammatory agent-induced gastric ulcer.
- Short-term treatment of active duodenal ulcer and active benign gastric ulcer.
- Maintenance therapy following healing of gastric ulcer to reduce ulcer recurrence.
- Adjunct to mifepristone for the medical termination of intrauterine pregnancy according to the “National Guideline on reproductive health care services” issued together with the Minister of Health’s Decision No. 4128 / QD-BYT dated July 29, 2016.
Contraindications
Pregnant women and women planning a pregnancy.
Allergic to misoprostol or other prostaglandins or any component of the drug.
For indications for mifepristone support during pregnancy termination:
- Absolute contraindications:
- Mitral valve stenosis, embolism and history of embolism.
- Adrenal gland disease.
- Blood coagulation disorders, using anticoagulants.
- Anemia (severe and moderate).
- Confirmed or suspected ectopic pregnancy.
- Pregnant at the old surgical wound in the uterus.
- Vegetable with comb teeth.
Relative contraindications:
- Long-term treatment with systemic steroids.
- Are acute genital tract infections.
- Genital deformities.
- Scarring of uterus with caution.
Dosage and administration
Adults:
- Prevention of NSAID-induced ulcers: 200mcg 4 times daily, reduce doses to 100mcg 4 times daily in patients who do not tolerate the usual dosage.
- Gastric ulcer: 100 – 200mcg 4 times daily for 8 weeks.
- Duodenal ulcer: 100 – 200mcg 4 times daily or 400mcg twice daily for 4 – 8 weeks.
- Support mifepristone in abortion: In accordance with “National Guideline on reproductive health care services” issued together with Decision No. 4128 / QD-BYT dated July 29, 2016 of the Minister of Health.
Precaution
- Caution in patients with pre-existing cardiovascular disease, enteritis, patients prone to dehydration.
- Self-use of abortion pills can be life-threatening, please follow the instructions of the treating physician and National guidelines on reproductive health care services specified in Decision No. 4128/QD-BYT dated July 29, 2016 of the Minister of Health.
- Misoprostol should not be used by nursing women.
- Patients should be cautious when driving or operating machinery because misoprostol may cause dizziness.
Storage
Store at temperature below 30°C, protect from light.
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