Indications
- Treatment or prevention of gastric ulcers, duodenal ulcers.
- In combination with appropriate antibiotics, Helicobacter pylori (H. pylori) eradication in peptic ulcer disease.
- Treatment or prevention of NSAID-associated gastric and duodenal ulcers.
- Treatment of reflux oesophagitis.
- Treatment of symptomatic gastro-oesophageal reflux disease.
- Treatment of Zollinger-Ellison syndrome.
Contraindications
- Hypersensitivity to any the ingredients.
Compositon/Ingredients
Omeprazole 20mg
Dosage and administration
Adults
Treatment of gastric ulcers, duodenal ulcers
- The recommended dose is 20 mg once daily. If needed, the dose can be increased 40 mg once daily. Ulcer healing time is usually 2-4 weeks for duodenal ulcers and 4-8 weeks for gastric ulcers .
Prevention of relapse of gastric ulcers, duodenal ulcers
- The recommended dose is 20 mg once daily. In patients with poorly responsive, the dose can be increased 40 mg once daily.
In combination with antibiotics in treatment of duodenal ulcer caused by H.pylori
- Omeprazole 20 mg twice daily, can be combined with antibiotics for the eradication of H. pylori. The selection of antibiotics should consider the individual patient's drug tolerance and should be undertaken in accordance with national, regional and local resistance patterns and treatment guidelines.
Treatment of NSAID-associated gastric and duodenal ulcers
- The recommended dose is 20 mg once daily. In most patients healing occurs within four weeks. In patients with poorly responsive, healing is usually achieved within eight weeks .
Prevention of NSAID-associated gastric and duodenal ulcers
- The recommended dose is omeprazole 20 mg once daily.
Treatment of reflux oesophagitis
- The recommended dose is omeprazole 20 mg once daily. In patients with severe oesophagitis omeprazole 40 mg once daily is recommended and healing occurs within four weeks and may last 8 weeks for patients with severe inflammation or poor response
Treatment of symptomatic gastro-oesophageal reflux
-The recommended dose is 20 mg daily. Patients may respond adequately to 10 mg daily. If symptom control has not been achieved after four weeks treatment with 20 mg daily, further investigation is recommended.
Treatment of Zollinger-Ellison syndrome
- The recommended initial dose is 60 mg daily. The dose should be individually adjusted and treatment continued as long as clinically indicated. All patients with severe disease and inadequate response to other therapies have been effectively controlled and more than 90% of the patients maintained on doses of omeprazole 20-120 mg daily. When dose exceed omeprazole 80 mg daily, the dose should be divided and given twice daily. Children
Children > 2 vear of age and > 20kg
- Posology: 20mg once daily. If needed, the dose can be increased 40 mg once daily.
- The treatment time:
+ Reflux oesophagitis: 4-8 weeks.
+ Symptomatic treatment of heartburn and acid regurgitation in gastro - oesophageal reflux disease: 2 - 4 weeks. If symptom control has not been achieved after 2-4 weeks, further investigation is recommended.
Children and adolescents over 4 years of age:
- In combination with antibiotics in treatment of duodenal ulcer caused by H.pylori: Omeprazole 20 mg/day, dosage of antibiotics should consider the individual patient's weight.
- The treatment time: 1-2 weeks.
Renal impairment: Dose adjustment is not needed in patients with impaired renal function.
Hepatic impairment: In patients with impaired hepatic function a daily dose of 20 mg may be sufficient.
Elderly: Dose adjustment is not needed in the elderly, if liver function is normal.
Storage
Store at temperature below 30°C, protect from light.
