Apitim 5mg (3 blisters x 10 capsules/box)

Indications

• Amlodipine is used alone or in combination with other classes of antihypertensive agents in the management of hypertension.
• Amlodipine also is used for the management of Prinzmetal variant angina and chronic stable angina pectoris. The drug has been used alone or in combination with other antianginal agents.

Contraindications

Patients who are hypersensitive to amlodipine, to any other calcium antagonist, or any ingredient in the formulation.

Compositon/Ingredients

Dosage and administration

Hypertension

• Adults: The usual initial dosage of amlodipine is 2.5 – 5 mg once daily. In geriatric and small frail individuals, an initial dosage of 2.5 mg once daily is recommended. Subsequent dosage of amlodipine should be adjusted according to the patient’s blood pressure response and tolerance and usually should not exceed 10 mg once daily. The usual maintenance dosage of amlodipine for the management of hypertension in adults is 5 –10 mg once daily.
• Children 6 years of age and older: The usual effective dosage of amlodipine is 2.5 – 5 mg once daily.

Angina

For the management of Prinzmetal variant angina or chronic stable angina, the usual adult dosage is 5 –10 mg once daily. In geriatric patients, the lower dosage of 5 mg once daily is recommended. Maintenance dosage is 10 mg daily.

Precaution

• Amlodipine should be used with caution in patients with hypotension, cardiac reserve is poor, heart failure
• The drug should not be used in cardiogenic shock, in patients who have suffered a myocardial infarction in the previous 2 to 4 weeks, or in acute unstable angina, in treatment an anginal attack in chronic stable angina.
• In patients with severe aortic stenosis amlodipine may increase the risk of developing heart failure. Sudden withdrawal of amlodipine might be associated with an exacerbation of angina.
• The dose may need to be reduced in patients with hepatic impairment.
• Amlodipine should not be administered during pregnancy, or lactation, or to women of childbearing potential unless effective contraception is used.
• Patients should be aware of how they react to drug before driving or operating machinery. Caution is recommended especially at the start of treatment.

Storage

Store at temperature below 30°C, protect from light.