Indications
Prevention of atherothrombotic events in:
Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months) or established peripheral arterial disease.
Adult patients who suffering from acute coronary syndrome with non-ST segment elevation (unstable angina or non-Q-wave myocardial infarction), including patients undergoing a stent placement; or patients with ST segment elevation acute myocardial infarction receiving medically treated eligible for thrombolytic therapy.
Prevention of atherothrombotic and thromboembolic events including stroke in adult patients with atrial fibrillation who have at least one risk factor for vascular events, are not suitable for treatment with vitamin K antagonists (VKA) and who have a low bleeding risk.
Contraindications
Known hypersensitivity to any of the active substance or excipients.
Presence of active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage).
Severe hepatic impairment.
Compositon/Ingredients
Clopidogrel 75mg
Dosage and administration
Adults and elderly: A single daily dose of 1 tablet.
In non-ST segment elevation acute coronary syndrome: Initiate with a single 4-tablet loading dose and then continued at 1 tablet once a day (with aspirin ≤ 100 mg daily).
In ST segment elevation acute myocardial infarction: Initiate with a 4-tablet loading dose in combination with aspirin and with or without thrombolytics, for at least 4 weeks, continued at 1 tablet once a day. For patients over 75 years of age, clopidogrel should be initiated without a loading dose.
In atrial fibrillation: A single daily dose of 1 tablet in combination with aspirin (75 – 100 mg daily).
Precaution
Clopistad should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery or other pathological conditions; patients with renal impairment, moderate hepatic disease who may have bleeding diatheses.
Clopistad cannot be recommended during the first 7 days after acute ischaemic stroke.
Clopistad should be used during pregnancy only if clearly needed. Discontinue nursing or discontinue Clopistad in breastfeeding woman.
Patients should be aware of how they react to drug before driving or operating machinery.
Storage
Store at temperature below 30°C, protect from light.
