Indications
- Hypertension, particularly in patients who develop cough with ACE inhibitors and to reduce the risk of stroke in patients with left ventricular hypertrophy.
- Diabetic nephropathy (as serum creatinine is 1.3 – 3.0 mg/dl in patients ≤ 60 kg and 1.5 – 3.0 mg/dl in males > 60 kg and proteinuria).
- Heart failure and in myocardial infarction.
Contraindications
Known hypersensitivity to any of the active substance or excipients.
Compositon/Ingredients
Losartan 25mg
Dosage and administration
Hypertension:
Adults: 50 mg once daily. The dose may be increased, if necessary, to 100 mg daily as a single dose or in two divided doses.
Patients with intravascular fluid depletion, hepatic or renal impairment: An initial dose of 25 mg once daily.
Children ≥ 6 years: An initial dose of 0.7 mg/kg once daily, with a maximum of 50 mg, adjusted according to response.
Nephropathy in type 2 diabetic patients:
An initial dose of 50 mg once daily, increased to 100 mg once daily depending on the blood pressure.
Precaution
Losartan should be used with caution in patients with renal artery stenosis, patients with volume depletion and the elderly.
Doses reduction may be required in patients with renal impairment and should be considered in patients with hepatic impairment.
When pregnancy is detected, losartan should be discontinued as soon as possible. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Patients should be aware of how they react to drug before driving or operating machinery.
Storage
Store at temperature below 30°C, protect from light.
