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Compositon/Ingredients: Misoprostol

Misoprostol is a synthetic substance similar to prostaglandin E1. In the digestive tract, misoprostol has the effect of inhibiting gastric acid secretion, protecting the gastric and duodenal mucosa, and increasing the healing of gastric and duodenal ulcers. The drug reduces gastric acid secretion by direct action on the gastric parietal cells, inhibiting the secretion of basic acid and also when stimulated by food, histamine, pentagastrin, tetragastrin, betazol, NSAIDs, alcohol or caffeine. Misoprostol also inhibits nocturnal gastric acid secretion, but does not reduce the volume of secretion. On the kidneys and genitourinary system: misoprostol increases the amplitude and frequency of uterine contractions, stimulates uterine bleeding and expels part or all of the contents of the uterus in pregnant women pregnancy.

Tư vấn sử dụng thuốc Dược sĩ Alphabet Pharma

Các biệt dược lưu hành (Tên thương mại):

Indications

Reducing the risk of nonsteroidal anti-inflammatory agent-induced gastric ulcer.
Short-term treatment of active duodenal ulcer and active benign gastric ulcer.
Maintenance therapy following healing of gastric ulcer to reduce ulcer recurrence.
Adjunct to mifepristone for the medical termination of intrauterine pregnancy according to the “National Guideline on reproductive health care services” issued together with the Minister of Health’s Decision No. 4128 / QD-BYT dated July 29, 2016.

Contraindications

Pregnant women and women planning a pregnancy.

Allergic to misoprostol or other prostaglandins or any component of the drug.

For indications for mifepristone support during pregnancy termination:

Absolute contraindications:
Mitral valve stenosis, embolism and history of embolism.
Adrenal gland disease.
Blood coagulation disorders, using anticoagulants.
Anemia (severe and moderate).
Confirmed or suspected ectopic pregnancy.
Pregnant at the old surgical wound in the uterus.
Vegetable with comb teeth.

Relative contraindications:

Long-term treatment with systemic steroids.
Are acute genital tract infections.
Genital deformities.
Scarring of uterus with caution.

Dosage and administration

Adults:

Prevention of NSAID-induced ulcers: 200mcg 4 times daily, reduce doses to 100mcg 4 times daily in patients who do not tolerate the usual dosage.
Gastric ulcer: 100 – 200mcg 4 times daily for 8 weeks.
Duodenal ulcer: 100 – 200mcg 4 times daily or 400mcg twice daily for 4 – 8 weeks.
Support mifepristone in abortion: In accordance with “National Guideline on reproductive health care services” issued together with Decision No. 4128 / QD-BYT dated July 29, 2016 of the Minister of Health.

Precaution

Caution in patients with pre-existing cardiovascular disease, enteritis, patients prone to dehydration.
Self-use of abortion pills can be life-threatening, please follow the instructions of the treating physician and National guidelines on reproductive health care services specified in Decision No. 4128/QD-BYT dated July 29, 2016 of the Minister of Health.
Misoprostol should not be used by nursing women.
Patients should be cautious when driving or operating machinery because misoprostol may cause dizziness.

Storage

Store at temperature below 30°C, protect from light.

Medicines containing compositon Misoprostol

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